These responses to exercise are not necessarily negative, but rather are a necessary part of the adaptation process, providing the level of stress does not exceed the ability of the body to recover. Although such gains can lead to enhanced athletic performance and may reduce the demands of activities of daily living, paradoxically resistance exercise increases markers of oxidative stress, skeletal and cardiac muscle damage, and transiently reduces physical performance. Resistance exercise is a powerful stimulus to induce gains in strength and hypertrophy. These benefits were seen with minimal energy intake. This occurred along with a prevention of the decrease in handgrip strength seen following the intense exercise protocol, indicating a potential reduction in central fatigue. This study demonstrated that tart cherry extract reduced oxidative stress and markers of muscle and cardiac damage following intense resistance exercise. There was a significant increase in handgrip strength in TC when compared to PL (PL: − 2 ± 5.1 vs. There was a significant ( p = 0.003) increase in CKMB concentration in PL when compared to the TC (PL: 21.6 ± 12.4 vs. There was a significant increase in CK activity in PL when compared to the TC at IP (PL: 491.1 ± 280 vs. There was a significant increase in PC in the placebo (PL) condition when compared to the Tart Cherry (TC) condition at Immediate Post (IP) (PL: 0.4 ± 0.3 vs. Physical performance was measured by countermovement jump power and handgrip dynamometer strength. Muscle soreness was assessed by visual analog scale. Serum protein carbonyl (PC) content, creatine kinase activity (CK) and creatine kinase myocardial band content (CK-MB) were used to assess oxidative stress, skeletal and cardiac muscle damage respectively. The protocol was performed once following 7 days of 500 mg of tart cherry extract and once following placebo. Thirteen men (mean age: 26.2 ± 5.3 years height: 184.3 ± 8.2 cm weight: 92.9 ± 15.6 kg) performed a demanding resistance exercise protocol consisting of 6 sets of 10 repetitions of barbell back squat with 80% 1RM. The primary purpose of this study was to assess whether powdered tart cherry extract with minimal calorie content reduces oxidative stress and enhances recovery following intense resistance exercise. The majority of these studies used tart cherry juice, with a significant calorie content. However, larger and longer follow-up studies are needed to further assess cardio-protective effects of tart cherry juice.Tart cherry supplementation has been shown to enhance recovery from strenuous exercise due to its antioxidant properties. Our findings show that tart cherry juice can lower the levels of systolic BP and LDL cholesterol. Neither tart cherry juice nor control significantly altered body weight, high-density lipoprotein cholesterol, diastolic BP, insulin and HOMA-IR. At the end of the study, participants in the tart cherry group had lower levels of LDL cholesterol (difference of -20.6 with P = 0.001) and total cholesterol (difference of -19.11 with P = 0.01), and higher levels of glucose (difference of 7.94 with P = 0.001), triglycerides (difference of 6.66 with P = 0.01) and BMI (difference of 1.06 with P = 0.02) than in the control group. Systolic BP and low-density lipoprotein cholesterol (LDL) exhibited treatment × time interaction effects. Outcome variables were assessed at baseline and after 12 weeks of tart cherry juice or control drink. Control beverages were matched for energy and sugar content. In this randomized-controlled clinical trial, 17 men and 20 women between the ages of 65-80 years were randomly assigned to consume 480 ml of tart cherry juice or control drink daily for 12 weeks. We examined the effects of tart cherry juice on lipid profiles, BP, glucose, insulin, and homeostatic model assessment-insulin resistance (HOMA-IR) in older adults. Common treatments for high blood pressure (BP) and dyslipidemia include medications, but there is question as to whether natural sources may be adequate to reduce CVD risk factors. Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD).
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